Single detmold

Single detmold

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Try out PMC Labs and tell us what you think. Learn More. a Institute of Pathology, University Hospital OWL of the University of Bielefeld, Campus Lippe, Detmold, Germany. b Department of Internal Medicine, Gastroenterology and Infectious Medicine, University Single detmold OWL of the University of Bielefeld, single detmold, Campus Lippe, Detmold, Germany. A previously symptomless year-old man received the first dose of the BNTb2 mRNA COVID vaccine.

He died 4 weeks later from acute renal and respiratory failure, single detmold. Although he did not present with any COVIDspecific symptoms, he tested positive for SARS-CoV-2 before he died. Acute bronchopneumonia and tubular failure were assigned as the cause of death at autopsy; however, we did not observe any characteristic single detmold features of COVID Postmortem molecular mapping by real-time polymerase chain reaction revealed relevant SARS-CoV-2 cycle threshold values single detmold all organs examined oropharynx, olfactory mucosa, trachea, lungs, heart, kidney and cerebrum except for the liver and olfactory bulb, single detmold.

These results might suggest that the first vaccination induces immunogenicity but not sterile immunity. We report on an year-old male resident of a retirement home who received vaccine against SARS-CoV Past medical history included systemic arterial hypertension, chronic venous insufficiency, dementia and prostate carcinoma.

On January 9,single detmold, the man received lipid nanoparticle-formulated, nucleoside-modified RNA vaccine BNTb2 in a 30 μg dose. On that day and in the following single detmold weeks, he presented with no clinical symptoms Table 1. On day 18, he was admitted to hospital for worsening diarrhea. Since he did not present with any clinical signs of COVID, isolation in a specific setting did not occur. Laboratory testing revealed hypochromic anemia and increased creatinine serum levels.

Antigen test and polymerase chain reaction PCR for SARS-CoV-2 were negative. RT-PCR, real-time polymerase chain reaction; Ct, cycle threshold. Gastroscopy and colonoscopy were performed to investigate the cause of diarrhea further. Colonoscopy, in particular, demonstrated an ulcerative lesion of the left colonic flexure, which was histologically diagnosed as ischemic colitis.

PCR-analysis on biopsy specimens, following a previously reported method Kaltschmidt et al, single detmold. Treatment was supportive with mesalazine and intravenous iron substitution. On day 24, a patient in the same hospital room as our case tested positive for SARS-CoV On day 25, our patient tested SARS-CoV-2 positive by real-time PCR RT-PCRwith a low cycle threshold Ct value indicating high virus load. On further analysis of the swab sample, there was no evidence for mutant SARS-CoV-2 variants B.

Taken together, it appears the patient became infected from the patient in his hospital room. Our patient now presented with fever and respiratory discomfort, and lung auscultation displayed crackles.

Despite starting supplemental oxygen 2 l per minute and antibiotic therapy by ceftriaxone, the patient died from acute renal and respiratory failure on the following day. Immunogenicity assessment by measuring spike protein S1 antigen-binding immunoglobulin Ig G in the serum samples obtained at day 25 showed antibody response 8.

These results indicate that the patient had already developed relevant immunogenicity single detmold vaccination. Postmortem study revealed acute bilateral bronchopneumonia with abscesses, sometimes being surrounded by bacterial cocci Figure 1. There were no findings of commonly described manifestations of COVIDassociated pneumonitis. In the heart, we found biventricular hypertrophy weight g and histologically, we diagnosed ischemic cardiomyopathy.

We detected amyloidosis of the transthyretin type in the heart and to a lesser extent in the lungs. The kidneys revealed both chronic damage with arteriolosclerosis and interstitial fibrosis, and acute renal failure with hydropic tubular degeneration. The examination of the brain revealed a left parietal pseudocystic tissue necrosis, single detmold, which was diagnosed as an old infarction area. Synopsis of the relevant histological findings and the results of molecular mapping is presented.

The histomorphology is obtained by standard hematoxylin and eosin reaction, except for the myocardium on the right side Congo red staining.

The magnification is shown by bars. Note that in the lungs, we also observed colonies of cocci arrow in granulocytic areas. In addition, single detmold, single detmold results of molecular mapping are given as evaluated cycle threshold values of the real-time polymerase chain reaction for SARS-CoV Note that only in the olfactory bulb and the liver SARS-CoV-2 could not be detected.

Single detmold conducted molecular mapping of 9 different anatomical parts of formalin-fixed paraffin-embedded tissue as previously described Kaltschmidt et al.

RNA was extracted from paraffin sections using the Maxwell RSC Promega, Madison, WI, USA. We examined 9 different tissue samples for known and relevant pathways of virus spreading in the human body Figure 1, single detmold. We demonstrated viral RNA in nearly all organs examined except for the liver and the olfactory bulb Figure 1. We suggest that a single treatment with BNTb2 RNA vaccine elicited significant immunogenicity, as reflected in the reported spike protein-based neutralizing IgG serum values.

From the weeks before vaccination, through single detmold day 1to shortly before death day 24the patient was free of any clinical symptoms typically ascribed to COVID Furthermore, blood work did not show an IgM titer that is generally observed 7—14 days after symptom onset Kim et al. However, the patient tested SARS-CoV-2 positive. Both the Ct value measured in nasopharyngeal single detmold and values measured in formalin-fixed paraffin-embedded autopsy specimens indicate viral load and suggest transmissibility.

Because our patient died approximately 2 days after his first positive SARS-CoV-2 test result, we suppose that the single detmold mapping data reflects an early stage of viral infection. An early stage of infection might also explain why different regions such as the olfactory bulb and liver were not yet affected by systemic viral spread.

We did not observe any characteristic morphological features of COVID reported in comprehensive morphological autopsy studies so far Schaller et al. We did not find any typical signs of diffuse alveolar damage in the lungs, but we single detmold extensive acute bronchopneumonia, possibly of bacterial origin, single detmold. We concluded that the patient died from bronchopneumonia and acute renal failure.

Our findings are in line with previous evidence from animal models that immunization against SARS-CoV-2 by vaccination appeared to reduce the severity of pathogenesis, especially with regard to severe lung disease, while viral RNA persisted in nasal swabs Van Doremalen et al, single detmold. Recently, Amit et al. Concerning major adverse effects in patients receiving vaccination against SARS-CoV-2, single detmold, local effects predominate, and severe systemic reactions are rarely described Yuan et al.

However, recent reports of an increased risk of blood clots, single detmold, particularly of cerebral venous sinus thrombosis in the case of the Oxford-AstraZeneca vaccine Mahaseraised a matter of debate on the safety of COVID vaccine in general. Comprehensive analysis of autopsy data must be performed to provide more detailed insights into lethal adverse effects and any deaths associated with vaccination. In summary, the results of our autopsy case study in a patient with mRNA vaccine confirm the view that by first dose of vaccination against SARS-CoV-2 immunogenicity can already be induced, while sterile immunity is not adequately developed, single detmold.

The authors do not have any commercial or financial conflict of interest. Informed consent by the next-of-kin was available, single detmold.

There was no funding received from any individual or organization. We are single detmold for the expert technical assistance of Ralf Bode and Nadine Weber University Hospital of OWL of the University of Bielefeld, single detmold, Campus Lippe, Detmold. National Center for Biotechnology InformationU. National Library of Medicine Rockville PikeBethesda MDUSA, single detmold. NCBI Skip single detmold main content Skip to navigation Resources How To About NCBI Accesskeys My NCBI Sign in to NCBI Sign Out.

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Journal List Elsevier Public Health Emergency Collection PMC Int J Infect Dis. Published online Apr doi: PMCID: PMC Torsten Hansen a Institute of Pathology, University Hospital OWL of the University of Bielefeld, Campus Lippe, Detmold, Germany Find articles by Torsten Hansen.

Ulf Titze a Institute of Pathology, University Hospital OWL of the University of Bielefeld, Campus Lippe, Detmold, Germany Find articles by Ulf Titze.

Nidhi Su Ann Kulamadayil-Heidenreich b Department of Internal Medicine, Gastroenterology and Infectious Medicine, University Hospital OWL of the University of Bielefeld, Campus Lippe, Detmold, Germany Find articles by Nidhi Su Ann Kulamadayil-Heidenreich. Sabine Glombitza c Institute of Pathology, Single detmold Hospital Nordstadt, Hannover, Germany Find articles by Sabine Glombitza. Johannes Josef Tebbe b Department of Internal Medicine, Gastroenterology and Infectious Medicine, University Hospital OWL of the University of Bielefeld, Campus Lippe, Detmold, Germany Find articles by Johannes Josef Tebbe.

Christoph Röcken d Institute of Pathology single detmold the University of Schleswig-Holstein, single detmold, Campus Kiel, Germany Find articles by Christoph Röcken. Birte Schulz a Institute of Pathology, University Hospital OWL of the University of Bielefeld, Campus Lippe, Detmold, Germany Find articles by Birte Schulz.

Michael Weise b Department of Internal Medicine, Gastroenterology and Infectious Medicine, University Hospital OWL of the University of Bielefeld, Campus Lippe, Detmold, Germany Find articles by Michael Weise, single detmold. Ludwig Wilkens c Institute of Pathology, KRH Hospital Nordstadt, single detmold, Hannover, Germany Find articles by Ludwig Wilkens. Author information Article notes Copyright and License single detmold Disclaimer.

c Institute of Pathology, KRH Hospital Nordstadt, Hannover, Germany. d Institute of Pathology of the University of Schleswig-Holstein, Campus Kiel, Germany, single detmold. Received Feb 25; Revised Apr 13; Accepted Apr Copyright © The Author s, single detmold. Since January Elsevier has created a Single detmold resource centre with free information in English and Mandarin on the novel coronavirus COVID The Single detmold resource centre is hosted on Elsevier Connect, the company's public news and information website.

Elsevier hereby grants permission to make all its COVIDrelated research that is available on the COVID resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source.

Single detmold permissions are granted for free by Elsevier for as long as the COVID resource centre remains active. Abstract A previously symptomless year-old man received the first dose of the BNTb2 mRNA COVID vaccine. Keywords: SARS-CoV-2, single detmold, Vaccine, Autopsy, Histology, single detmold, RT-PCR. Day 1 Day 15 Day 18 Day 19 Day 20 Day 23 Day 24 Day 25 Day 26 Major event Vaccination Collapse during breakfast Admission to hospital; gastroscopy mild gastritis Abdominal ultrasound, initiating intravenous iron application Colonoscopy ischemic colitisinitiating mesalazine Acute renal insufficiency, single detmold, initiating intravenous glucose application Patient in same hospital room has positive SARS-CoV-2 RT-PCR test Ct, 15 Patient somnolent, initiating antibiotic therapy, chest radiograph with minimal infiltrates Death at Leading clinical symptoms No relevant symptoms recorded No further relevant symptoms recorded Diarrhea Anemia Anemia Lung auscultation with any pathological signs, hypernatremia Hypernatremia Dehydration, lung auscultation with crackles Acute renal and respiratory failure Temperature °C Not recorded Not recorded Open in a separate window.

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 · We suggest that a single treatment with BNTb2 RNA vaccine elicited significant immunogenicity, as reflected in the reported spike protein-based neutralizing IgG serum values. From the weeks before vaccination, through vaccination (day 1), to shortly before death (day 24), the patient was free of any clinical symptoms typically ascribed to COVIDLocation: Rockville Pike, Bethesda, MD The Hermannsdenkmal (German for "Hermann's Monument") is a monument located southwest of Detmold in the district of Lippe, (North Rhine-Westphalia) in blogger.com stands on the densely forested Grotenburg [], sometimes also called the Teutberg or Teut, a hill (elevation m) in the Teutoburger Wald (Teutoburg Forest) range. The monument is located inside the remains of a circular rampart Detpak's cups and cup accessories accessories consider sustainability with ranges like our RecycleMe™ takeaway coffee cups, our Precision Series